| Rotation # and Type | Week # | PICO/Mini-CAT/CAT | Question |
| RT 1 – LTC | WK #2 | PICO | In elderly patients with major depressive disorder, is treatment with Sertraline plus aerobic exercise more effective in improving depressive symptoms, such as low mood and loss of interest, than treatment with Sertraline alone? |
| RT 1 – LTC | WK #4 | PICO | In elderly patients with T2DM and NAFLD/NASH, is treatment with Metformin plus Empagliflozin (Jardiance) more effective than Metformin alone in treating both diabetes and non-alcoholic fatty liver disease? |
| RT 2 – OB/GYN | WK #2 | PICO | In first trimester pregnant patients seeking medical abortion treatment for an unwanted pregnancy, is treatment with Misoprostol alone as effective as combination treatment with Mifepristone and Misoprostol? |
| RT 2 – OB/GYN | WK #4 | PICO | For a 32 y/o G1P0000 40w2d female, is intravenous administration of Oxytocin more effective than intramuscular administration of Oxytocin in preventing postpartum hemorrhage following an expected vaginal delivery? |
| RT 3 – EMED | WK #2 | PICO | For diabetic patients with oral lichen planus, is treatment with photodynamic therapy as effective as corticosteroids in resolving symptoms? |
| RT 3 – EMED | WK #3 | PICO | For symptomatic patients with paroxysmal atrial fibrillation [PAF] who have never been treated with antiarrhythmic drug therapy, is initial treatment with cryoballoon catheter ablation more effective than antiarrhythmic drug therapy in preventing symptom recurrence and treating symptomatic PAF? |
| RT 3 – EMED | WK #4 | PICO | For patients who present to the ED with moderate to severe alcohol withdrawal syndrome, is adjunctive treatment with IV barbiturates in combination with benzodiazepines more effective in treating alcohol withdrawal syndrome than treatment with benzodiazepines alone? |
| RT 4 – SURGERY | WK #4 | MINI-CAT | In first trimester pregnant patients seeking medical abortion treatment for an unwanted pregnancy, is treatment with Misoprostol alone as effective as combination treatment with Mifepristone and Misoprostol? |
| RT 5 – PEDIATRICS | WK #1 | PICO | Does daily application of emollients reduce risk for atopic dermatitis and food allergy for newborn infants at increased risk compared to no intervention at all? |
| RT 5 – PEDIATRICS | WK #2 | PICO | For preterm neonates with patent ductus arteriosus, is Paracetamol, or Acetaminophen, safer and more effective than Ibuprofen for PDA closure? |
| RT 6 – AMBULATORY MEDICINE | WK #1 | PICO | For women of child-bearing age diagnosed with Trichomoniasis, who do not have other infections, including HIV or bacterial vaginosis, is a multi-dose regimen of Metronidazole 500 mg twice daily for 7 days more effective than a single 2 gram dose of Metronidazole? |
| RT 6 – AMBULATORY MEDICINE | WK #4 | MINI-CAT | For preterm neonates with patent ductus arteriosus, is Acetaminophen (Paracetamol) safer and more effective than Ibuprofen for PDA closure? |
| RT 7 – FAMILY MEDICINE | WK #2 | PICO | In elderly male patients with intermittent claudication related to peripheral artery disease, is treatment with endovascular revascularization plus supervised exercise more effective than supervised exercise alone? |
| RT 7 – FAMILY MEDICINE | WK #3 | PICO | In men who have sex with men diagnosed with rectal chlamydia, is treatment with Doxycycline 100 mg twice a day for seven days more effective than treatment with a single dose of 1 g of Azithromycin? |
| RT 7 – FAMILY MEDICINE | WK #4 | PICO | In women seeking to reduce depressive symptoms and prevent postpartum depression, are exercise-based interventions more effective than non-intervention or standard care (antidepressants or cognitive behavioral therapy)? |
| RT 9 – PSYCHIATRY | WK #4 | CAT | In women seeking to reduce depressive symptoms and prevent postpartum depression, are exercise-based interventions more effective than non-intervention or standard care (antidepressants or cognitive behavioral therapy)? |
